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30L-240L Fixed Bed Bioreactor

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Product Application
● Cultivation of Vero, ST and other adherent cells in sheet-like carriers ● Development and production of production processes for vaccines and recombinant proteins
● Process development, optimization, and identification ● Zoom in and out research
● Small scale production, pilot scale production ● Process strategy development using flow, continuous, or infusion modes

  • Product Features
  • Product Parameters
  • Control Accuracy and Range
  • Product Disassembly Diagram
  • Case Presentation

  • ● One-button automatic sterilization technology with cold spot temperature measurement to ensure sterilization reliability 

    ● CFD-based fluid simulation stirring system ensures efficient mixing 

    ● Two-way temperature control for cooling and heating, self-adaptive PID, unaffected by ambient temperature; temperature control accuracy ±0.1°C, no overshoot during rapid temperature rise 

    ● Dual-mode dissolved oxygen control with oxygen and compressed air, auto-switching to accommodate DO control in different growth stages 

    ● Unlimited sampling for one-time sterilization, with no residual liquid discharge, ensuring safety and reliability 

    ● Preset process parameters, real-time data, fault alarms, login/logout records, and operation logs are permanently stored and can be accessed for analysis at any time 

    ● Internet connectivity enables remote monitoring and control via mobile or computer 

    ● Self-inspection during startup and cell culture processes ensures stable control of cell culture 

    ● Pre-set automatic restart function; When power is restored after an outage, the equipment will automatically resume the pre-failure control state 

    ● Supports timed startup, shutdown, and automatic adjustment of control data 

    ● Equipped with curve recording functionality 

    ● Simple, quick, and safe pipeline operations 

    ● Standard modular design with components and PLC software library 

    ● Validated aseptic design and stability ensure process reliability 

    ● Proven hardware design and control software 

    ● Complies with cGMP and FDA requirements

  • ● Working volume: 20L-150L (total volume 30L-240L) ● Tank material: 316L stainless steel tank body
    ● Polishing requirement: Inner polishing ≤ 0.4 μ m ● Sterilization method: Fully automatic online sterilization, with a cold spot thermometer to ensure sterilization effectiveness
    ● Temperature control: electric heating, cold water heat exchanger cooling ● Tank structure: with jacket and insulation layer
    ● Mixing method: Multiple mixing methods are available, and different mixing methods are chosen for different cultivation volumes ● Surface intake: Surface compressed air intake
    ● Deep intake: including oxygen, carbon dioxide, and compressed air three-way intake (expandable) ● Intelligent pH electrode, optical DO electrode
    ● Peristaltic pump: Three sets of peristaltic pumps (expandable), adjustable from 0-100rpm, disposable ● Top integrated light mirror, side long strip mirror
    ● Safety guarantees such as bursting discs and pressure relief valves ● Control cabinet: 304 stainless steel control cabinet, personalized design, small footprint, easy maintenance, beautiful appearance
    ● Control software: Siemens PLC control, 12 "touch screen human-machine interaction  
  • ● Temperature control range: 20-40 ℃, control accuracy ± 0.1 ℃ ● PH control range: 2-12, control accuracy ± 0.02
    ● DO control range: 0-100% air saturation, control accuracy ± 5% ● Speed control range: 0-200rpm, control accuracy ± 0.1rpm
    ● Pressure control range: 0-1.5bar, control accuracy ± 0.1bar  

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